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KMID : 0378019780210050079
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New Medical Journal
1978 Volume.21 No. 5 p.79 ~ p.86
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Long Term Result after Eck´s Fistula in Rat
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Abstract
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Since the time of Eck, a Russian physiologist, who was the first to perform portasystemic shunt in experimental animal, many attempts have been made to apply this shunt for the relief of portal hypertension in the patients with cirrhosis. But increasing evidence has accumulated that portacaval shunts in normal animals may produce deterious affects and several investigators have been interested in the pathophysiologic changes induced by this shunt. The effect of Eck´s fistula has been intensively studied by various test animals. It was known that fatal outcome is usual when Eck fistula is made in the normal animals such as monkey, dog and pig. Many authors have reported the effect of Eck fistula in rats and agreed that the deversion of portal blood is not fatal in this small laboratory animal in contrast with the large animals. In the Department of Surgery of St. Mary´s Hospital, Eck fistula was carried out on rat as a experimental model and it was confirmed that the postoperative mortality and morbidity was negligible for short experimental duration. This experiment was performed to observe the changes of body weight, the biochemical and histological changes in rats with Eck fistula of two months´ duration. All the experimental rats were divided into 2 groups, one was the control group (Sham operation) and the other Eck fistula group. All these animals were checked daily body weight and sacrificed at 60th postoperative day and comparative liver weight, blood chemistry for liver function test and microscopic findings of several parenchymatous organs were studied. The result were as follows: 1. There was no lethal case of rat with Eck fistula during experimental period. 2. Weight curve of Eck fistula group demonstrated a considerable decreasing tendency until 25th postoperative day. But after then, gradual recovery of body weight was noted. 3. There was no considerable difference in liver weight/body weight ratio and liver function test between control and Eck fistula group. 4. In general, no significant changes were found on the microscopic observations of the parenchymatous organs in Eck fistula group except dilatation of centrilobular sinusoid of the liver and marked testicular atrophy. It was a interesting fact that long standing Eck fistula in normal male rat produced marked testicular atrophy. Eck fistula was thought to be a reproducible experimental model for the study of a deletion of hormonal metabolic activity of the liver.
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KEYWORD
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